Journal article
The Structural Connectome and Internalizing and Externalizing Symptoms at 7 and 13 Years in Individuals Born Very Preterm and Full Term
CP Gilchrist, DK Thompson, CE Kelly, R Beare, C Adamson, T Dhollander, K Lee, K Treyvaud, LG Matthews, M Tolcos, JLY Cheong, TE Inder, LW Doyle, A Cumberland, PJ Anderson
Biological Psychiatry Cognitive Neuroscience and Neuroimaging | ELSEVIER | Published : 2022
Abstract
Background: Children born very preterm (VP) are at higher risk of emotional and behavioral problems compared with full-term (FT) children. We investigated the neurobiological basis of internalizing and externalizing symptoms in individuals born VP and FT by applying a graph theory approach. Methods: Structural and diffusion magnetic resonance imaging data were combined to generate structural connectomes and calculate measures of network integration and segregation at 7 (VP: 72; FT: 17) and 13 (VP: 125; FT: 44) years. Internalizing and externalizing symptoms were assessed at 7 and 13 years using the Strengths and Difficulties Questionnaire. Linear regression models were used to relate network..
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Grants
Awarded by National Institutes of Health
Funding Acknowledgements
This study was funded in part by an Australian Government Research Training Program Scholarship (to CPG) , the Australian National Health and Medical Research Council (Center for Clinical Research Excellence Grant Nos. 546519, 1060733, and 1153176; Project Grant Nos. 237117, 491209, and 1066555; Career Development Fellowships 1085754 and 1160003 [to DKT] and 1141354 [to JLYC] ; Early Career Fellowship Grant No. 1012236 [to DKT] ; Senior Research Fellowship Grant No. 1081288 and Leadership Fellowship Grant No. 1176077 [to PJA] ) , Financial Markets Foundation for Children (Grant No. 2019-083 [to AC, PJA, DKT, MT] ) , RMIT Vice Chancel-lors Senior Research Fellowship and Australian Research Council Future Fellowship (to MT) , Brigham and Womens Hospital Program for Interdisci-plinary Neuroscience Fellowship (to LGM) , US National Institutes of Health (Grant No. HD058056) , Murdoch Childrens Research Institute, the Royal Childrens Hospital, The Royal Childrens Hospital Foundation, Department of Paediatrics, The University of Melbourne, and the Victorian Government's Operational Infrastructure Support Program.